STATISTICS

BENZ WS Content

EC 1 EC 2 EC 3 EC 4 EC 5 EC 6 EC 7 Total
EC numbers + 1,437 1,550 1,034 595 254 189 77 5,136
Cluster HMM 1,758 5,116 3,755 1,006 637 636 188 12,612
Cluster HMM GOLD 1,326 4,315 3,190 800 497 196 218 10,547
Cluster HMM BLUE 432 801 565 206 140 140 70 2,065
Ref Seq * 2,752 (390) 6,455 (990) 4,582 (729) 1,348 (324) 842 (145) 883 (105) 405 (14) 16,593 (2,023)
Ref Str * 1,230 (152) 2,252 (253) 2,100 (213) 625 (110) 333 (41) 287 (22) 149 (5) 6,798 (618)
PFAM ° 682 (429) 1,923 (769) 1,672 (711) 463 (321) 294 (190) 276 (133) 143 (50) 4,158 (1,758)
KEGG ID ^ 2,390 5,908 3,770 1,185 799 894 343 14,745
KEGG Pathway ^ 2,758 4,812 2,628 1,972 952 1,266 317 9,382
Organisms **
  • Arc: 15
  • Bac: 158
  • Euk: 200
  • Vir: 13
  • Arc: 20
  • Bac: 187
  • Euk: 232
  • Unk: 1
  • Vir: 193
  • Arc: 15
  • Bac: 165
  • Euk: 208
  • Unk: 1
  • Vir: 135
  • Arc: 13
  • Bac: 125
  • Euk: 141
  • Vir: 4
  • Arc: 16
  • Bac: 109
  • Euk: 83
  • Vir: 6
  • Arc: 18
  • Bac: 119
  • Euk: 53
  • Vir: 12
  • Arc: 7
  • Bac: 57
  • Euk: 47
  • Arc: 24
  • Bac: 261
  • Euk: 391
  • Unk: 2
  • Vir: 213
+ Four-level EC numbers distributed according to the 7 EC classes: EC1-Oxidoreductases, EC2-Transferases, EC3-Hydrolases, EC4-Lyases,EC5-Isomerases, EC6-Ligases, EC7-Translocases.
* Ref Seq and Ref Str: number of reference sequences, and reference sequence with structure, respectively; number of polyfunctional enzymes are within brackets.
° Pfam: models from Pfam (https://pfam.xfam.org) ; within brackets Pfams, where relevant sites (active, metal, ligand binding site) are annotated.
^ KEGG ID: from UniProt annotation; KEGG pathway: from https://www.genome.jp/kegg/.
** number of organisms detailed for each kingdom. Arc: Archaea; Bac: Bacteria; Euk: Eukaryota; Oth: Others; Vir: Viruses. Unk: unknown. Annotation source: UniProt. Grand Total: 891.

Polyfunctional☨︎ enzymes

EC 1 EC 2 EC 3 EC 4 EC 5 EC 6 EC 7 Total
EC numbers + 384 475 311 255 84 70 10 1,589
Cluster HMM 261 736 564 227 104 72 11 1,485
Cluster HMM GOLD 135 472 376 127 50 36 6 907
Cluster HMM BLUE 126 264 188 100 54 36 5 578
Ref Seq * 390 990 729 324 145 105 14 2,023
Ref Str * 152 253 213 110 41 22 5 618
PFAM ° 254 (207) 686 (389) 532 (302) 209 (169) 112 (90) 97 (61) 8 (5) 1,156 (725)
KEGG ID ^ 346 841 598 281 133 109 12 1,776
KEGG Pathway ^ 800 1,378 797 709 342 292 14 2,627
Organisms **
  • Arc: 4
  • Bac: 62
  • Euk: 63
  • Vir: 3
  • Arc: 11
  • Bac: 78
  • Euk: 83
  • Vir: 115
  • Arc: 9
  • Bac: 57
  • Euk: 56
  • Vir: 99
  • Arc: 8
  • Bac: 59
  • Euk: 72
  • Vir: 2
  • Arc: 7
  • Bac: 32
  • Euk: 38
  • Vir: 2
  • Arc: 5
  • Bac: 31
  • Euk: 16
  • Vir: 1
  • Bac: 6
  • Euk: 5
  • Arc: 12
  • Bac: 124
  • Euk: 145
  • Vir: 118
☨ For polyfunctional enzymes, four-level EC codes are counted independently for the seven enzymatic classes.
+ Four-level EC numbers distributed according to the 7 EC classes: EC1-Oxidoreductases, EC2-Transferases, EC3-Hydrolases, EC4-Lyases,EC5-Isomerases, EC6-Ligases, EC7-Translocases.
* Ref Seq and Ref Str: number of reference sequences, and reference sequence with structure, respectively; number of polyfunctional enzymes are within brackets.
° Pfam: models from Pfam (https://pfam.xfam.org) ; within brackets Pfams, where relevant sites (active, metal, ligand binding site) are annotated.
^ KEGG ID: from UniProt annotation; KEGG pathway: from https://www.genome.jp/kegg/.
** number of organisms detailed for each kingdom. Arc: Archaea; Bac: Bacteria; Euk: Eukaryota; Oth: Others; Vir: Viruses. Unk: unknown. Annotation source: UniProt. Grand Total: 384.
Polyfunctional Enzyme Distribution
Fig.1S Reference polyfunctional enzymes are grouped according to the associated number of four-level ECs (Grand Total: 2,023).